Quantitative Petri Net Models for the Heat Shock Response (bibtex)
by Gratie, Diana-Elena and Petre, Ion
Abstract:
The eukaryotic heat shock response is a highly conserved defense mechanism against cellular stress. We propose in this paper a quantitative Petri net- based representation of the heat shock response model introduced in [Petre et al., 2011]. We consider both a continuous and a stochastic representation, and analyze the properties of the networks. We extend the models to account for the heat-induced degradation of the self-defense mechanism itself, as well as its ability to repair itself. We conclude with an analysis of the simulation results, and a discussion on how modeling biological systems with Petri nets scales with further expansions of the model.
Reference:
Quantitative Petri Net Models for the Heat Shock Response (Gratie, Diana-Elena and Petre, Ion), Technical report 1068, , 2013.
Bibtex Entry:
@TechReport{t693,
  author   = {Gratie, Diana-Elena AND Petre, Ion},
  title    = {Quantitative Petri Net Models for the Heat Shock Response},
  year     = {2013},
  number   = {1068},
  abstract = {The eukaryotic heat shock response is a highly conserved defense mechanism against cellular stress. We propose in this paper a quantitative Petri net- based representation of the heat shock response model introduced in [Petre et al., 2011]. We consider both a continuous and a stochastic representation, and analyze the properties of the networks. We extend the models to account for the heat-induced degradation of the self-defense mechanism itself, as well as its ability to repair itself. We conclude with an analysis of the simulation results, and a discussion on how modeling biological systems with Petri nets scales with further expansions of the model.},
  file     = {CSCS19_2013-04-17-10-02.pdf:pdfs/CSCS19_2013-04-17-10-02.pdf:PDF},
  keywords = {Petri nets, reaction-based models, heat shock response, P-invariants, T-invariants.},
}
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