A simple mass-action model for the eukaryotic heat shock response and its mathematical validation (bibtex)

by Petre, Ion, Mizera, Andrzej, Hyder, Claire L., Meinander, Annika, Mikhailov, Andrey, Morimoto, Richard I., Sistonen, Lea, Eriksson, John E. and Back, Ralph-Johan

Abstract:

The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes.

Reference:

A simple mass-action model for the eukaryotic heat shock response and its mathematical validation (Petre, Ion, Mizera, Andrzej, Hyder, Claire L., Meinander, Annika, Mikhailov, Andrey, Morimoto, Richard I., Sistonen, Lea, Eriksson, John E. and Back, Ralph-Johan), In Natural Computing, volume 10, 2011.

Bibtex Entry:

@Article{j659, author = {Petre, Ion AND Mizera, Andrzej AND Hyder, Claire L. AND Meinander, Annika AND Mikhailov, Andrey AND Morimoto, Richard I. AND Sistonen, Lea AND Eriksson, John E. AND Back, Ralph-Johan}, title = {A simple mass-action model for the eukaryotic heat shock response and its mathematical validation}, journal = {Natural Computing}, year = {2011}, volume = {10}, number = {1}, pages = {595-612}, abstract = {The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes.}, keywords = {Heat shock response;Heat shock protein;Heat shock factor;Heat shock element;Mathematical model;Validation;Regulatory network}, }

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