A new mathematical model for the heat shock response (bibtex)
by Petre, Ion, Mizera, Andrzej, Hyder, Claire L., Mikhailov, Andrey, Eriksson, John E., Sistonen, Lea and Back, Ralph-Johan
Abstract:
We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.
Reference:
A new mathematical model for the heat shock response (Petre, Ion, Mizera, Andrzej, Hyder, Claire L., Mikhailov, Andrey, Eriksson, John E., Sistonen, Lea and Back, Ralph-Johan), Chapter in (Anne Condon et al, ed.), Springer, 2009.
Bibtex Entry:
@InBook{c179,
pages     = {411-425},
title     = {A new mathematical model for the heat shock response},
publisher = {Springer},
year      = {2009},
author    = {Petre, Ion AND Mizera, Andrzej AND Hyder, Claire L. AND Mikhailov, Andrey AND Eriksson, John E. AND Sistonen, Lea AND Back, Ralph-Johan},
editor    = {Anne Condon et al},
series    = {Natural Computing},
abstract  = {We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.},
booktitle = {Algorithmic bioprocesses},
file      = {PMHMESB2009b.pdf:pdfs/PMHMESB2009b.pdf:PDF},
keywords  = {Heat shock response, heat shock protein, heat shock factor, mathematical model, differential equations, model fit, sensitivity analysis},
}